Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody
نویسندگان
چکیده
منابع مشابه
PANCREATIC ISLET CELL SURFACE GLYCOPROTEINS CONTAINING Gall-4G1cNAc-R IDENTIFIED BY A CYTOTOXIC MONOCLONAL AUTOANTIBODY
The insulin-dependent diabetic syndromes of the BB rat and man have several characteristics in common that implicate autoimmune processes in the etiology of pancreatic a cell destruction . The main arguments in favor of this are early infiltration of the islets by mononuclear cells (1, 2), and the presence of islet cell cytoplasmic (ICA)' and surface autoantibodies (ICSA) (3). ICSA are immunocy...
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To investigate the autoimmune pathogenesis of spontaneously occurring diabetes mellitus in BB rats, spleen cells of newly diagnosed diabetic BB rats were fused with mouse myeloma cells. Hybridoma supernatants were screened for antibodies by indirect immunofluorescence and by 51Cr-release assays using the RINm5F rat insulinoma cell line. One clone, E5C2, produced an IgM kappa antibody that was c...
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We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocom...
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Pancreas plays an important role in maintaining the glucose homeostasis. The deterioration of β-cells in the pancreas is a crucial factor in the progression of diabetes mellitus; therefore, the restoration of β-cell mass and its function is of vital importance for effective therapeutic strategies. The precise mechanism for increase in functional β-cell mass is still unknown. This review focuses...
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BACKGROUND Islet 1 (ISL1), a LIM-homeodomain transcription factor is essential for promoting pancreatic islets proliferation and maintaining endocrine cells survival in embryonic and postnatal pancreatic islets. However, how ISL1 exerts the role in adult islets is, to date, not clear. METHODOLOGY/PRINCIPAL FINDINGS Our results show that ISL1 expression was up-regulated at the mRNA level both ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1990
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00404146